sigma single bond, pi-metal complex and cyclic molecules) 10. In addition, DNA can be modified in various ways and folded in many forms so as to enable the synthesized molecular devices to perform more complex operations, rather than based on simple movable linking fragments (e.g. Therefore, the construction of artificial intelligence molecular machines has a good connection with nanoscale molecular devices and simulated biological motors, which would draw a blueprint in the fields of biology and chemistry.ĭNA, owing to its highly parallel structure that can be accurately predicted and assembled, has been recognized as an ideal smart nanomaterial, and has been widely used in controllable molecular computing tools, construction of complex three-dimensional structures, and functional nanomachines 7– 9.
After about 40 years of development, researchers have designed and manufactured a large number of molecular machine components that can be assembled on the nanoscale like Lego bricks, including molecular switches, molecular ratchets, molecular motors, molecular linkages, molecular rings, and so on 4– 6. Similar to the assembly of macroscopic machines by machine components, molecular machines assemble various molecular units together and operate under external stimuli such as electrical, chemical or light energy, thereby realizing the overall operation of molecular machines 2, 3. connected two cyclic molecules into a chain and named it a catenane which took the first step towards molecular machines 1. As such, the DNA nano-dice system provides guideline and possibilities for the design, engineering, and quantification of behavioral probability simulation, a currently emerging area of molecular simulation research.
#Topface cheat series
We first discuss the randomness of DNA cube, or dice, adsorbing on graphene oxide, or table, and then explore a series of events that change the probability through the way in which the energy released from entropy-driven strand displacement reactions or changes in intermolecular forces. In this perspective we utilize DNA cube framework for the design of a dice device at the nanoscale to reproduce probabilistic events in different situations: equal probability, high probability, and low probability. Dice throwing, as a stochastic model, is commonly used for result judgment or plan decision in real life. Key to behavior simulation is to reproduce the specific properties of physical or abstract systems. Artificial molecular machines have captured the imagination of researchers, given their clear potential to mimic and influence human life.
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